13:00 – 13:15

Martin Stoddart (CH)

Sibylle Grad (CH)
Conference house keeping
Cartilage and Disc

15:15 – 15:45

Ivan Martin (CH)
Engineered nasal cartilage for osteoarthritis?

15:45 – 16:15

Keren Bismuth (FR)
Beneficial structural impact of liraglutide, a GLP1 receptor agonist, in inflammatory and post-traumatic OA animal models

16:15 – 16:30

R Hilliard, H Newman, A Barba, L Brewer, E Brewer, Z Brown, P Wilson,
A Lowman, DM Elliott, T Schaer
Nucleus pulposus replacement mitigates IVDD in a caprine model – a 3 year follow-up

16:30 – 17:00

Lisbet Haglund (CA)
Cell senescence and senolytic drugs to treat back-pain in mice and men

17:00 – 17:30

Francisco Blanco (ES)
Mitochondrial DNA variants influence the risk of Knee Osteoarthritis

17:30 – 17:45

P Humbert, M Garcia, L Jabbour, S Grastilleur, E Carrot, S Sourice, B Halgand, D Rouleau, F Etienne, A Lafragette, N Luciani, J Clouet, AKA Silva, F Gazeau, M Fusellier, J Guicheux, C Le Visage
Use of intervertebral disc cells from sheep to evaluate biotherapies in vitro

17:45 – 18:00

GQ Teixeira, J Kräutler, J Riegger, A Ignatius, C Neidlinger-Wilke
Effect of entire MSC secretome versus extracellular vesicles in pro-inflammatory annulus fibrosus cell cultures

18:00 – 18:15

R Ossendorff, V Börger, DC Wirtz, S Grad, B Giebel, FA Schildberg
Extracellular vesicles (MSC-EV) - influence on cartilage regeneration in osteoarthritic surroundings

18:15 – 18:30

 Riegger, L Ruths, G Teixeira, M Huber-Lang, A Ignatius, RE Brenner
Terminal complement complex is a potential inducer of premature senescence in trauma- and age-associated osteoarthritis

08:30 – 09:00

Frank Beier (CA)
What do mouse studies teach us about osteoarthritis?

09:00 – 09:30

Ali Mobasheri (CA)
Immunometabolism in disc and cartilage in health and disease

09:30 – 09:45

H Cherif, L Li, J Snuggs, C Sammon, L Beckman, L Haglund, C Le Maitre
Human organ culture model demonstrates potential regeneration of naturally degenerate discs with an injectable hydrogel system

09:45 – 10:00

A Alminnawi, KB Crump, P Bermudez-Lekerika, AS Croft, C Geeroms, C Le Maître, B Gantenbein, L Geris
Image-based analysis of mass transport through cartilage endplates

10:00 – 10:15

R Castro-Viñuelas, N Viudes-Sarrión, S Monteagudo, R Lories, I Jonkers
Excessive wnt signalling alters cartilage’s mechano-response in a human explant in vitro model

10:15 – 10:30

H Meng, S Fu, MB Ferreira, N Gavara, MM Knight
Activation of YAP suppresses cartilage inflammatory signalling and matrix degradation

11:00 – 11:30

Anne Camus (FR)
Generation of intervertebral disc progenitor cells from human induced pluripotent stem cells

11:30 – 12:00

Solvig Diederichs (DE)
Induced pluripotent stem cells for cartilage regeneration

12:00 – 12:15

LT Laagland, FC Bach, LB Creemers, C Le Maitre, DW Poramba-Liyanage, MA Tryfonidou
Hyperosmolar expansion medium improves canine nucleus pulposus cell phenotype

12:15 – 12:30

S Basatvat, TS Braun, E Kanelis, LG Alexopoulos, J Snuggs, R Williams, M Templin, M Tryfonidou, C Le Maitre
Could notochordal cells be the future of cell-based treatment for disc degeneration?

12:30 – 12:45

G Pattappa, J Jahns, R Schewior, J Zellner, D Docheva, P Angele
Identifying a unique gene profile for the meniscus cells in tissue and in vitro monolayer and pellet cultures

12:45 – 13:00

N Herger, L Arpesella, M Farshad, F Brunner, O Distler, S Dudli
Pro-inflammatory priming of mesenchymal stem cells increases their immunosuppressive properties only short-term

08:30 – 09:00

Fabio Galbusera (IT)
Computational modeling and artificial intelligence in spine research

09:00 – 09:30

Ilse Jonkers (BE)
An integrated, multi-scale approach to understand the role of mechanical loading in cartilage homeostasis and disease: Bridging from joint to chondrocyte

09:30 – 09:45

S Midha, T Johnson, CR Coveney, E Stride, JPK Armstrong, AKT Wann
The mechano-regulation of phenotypic plasticity studied in a developmental engineering model of endochondral ossification

09:45 – 10:00

JU Jansen, GQ Teixeira, A Vernengo, S Grad, K Benz, C Neidlinger-Wilke, HJ Wilke
How to create artificial disc degeneration by enzyme digestion for biomechanical testing of biomaterials

10:00 – 10:15

E Salzer, VHM Mouser, J Bulsink, MA Tryfonidou, K Ito
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus explants

10:15 – 10:30

A Ristaniemi, A Šećerović, S Grad, SJ Ferguson
A novel viscoelastic bovine intervertebral disc finite element model

11:00 – 11:30

Sylvia Nürnberger (AT)
Extracellular matrix as biomaterial for cartilage regeneration – more than a scaffold

11:30 – 12:00

Ling Qin (US)
Developing novel treatments for joint diseases

12:00 – 12:15

P Nakielski, C Rinoldi, M Pruchniewski, D Rybak, O Urbanek, K Jezierska-Woźniak, M Grodzik, W Maksymowicz, F Pierini
Injectable microscaffolds for IVD regeneration

12:15 – 12:30

B Günay, G Targa Fabra, L Laanglard, T Schmitz, K Ito, MA Tryfonidou, R Saldova, A Pandit
Glycomic enhancement of hyaluronic acid-based hydrogel with notochordal cell-derived matrix for disc regeneration

12:30 – 12:45

J Warren, R Cowie, L Jennings, R Wilcox, H Fermor
Self-assembling peptide gels for articular patella cartilage repair

12:45 – 13:00

E Carrot, P de Villemagne, S Grastilleur, B Rosa, B Halgand, V Delplace, J Clouet, P Weiss, Vidal, JY Hascoët, M Fusellier, J Guicheux, C Le Visage
Bioprinting and characterization of a sheep intervertebral disc model

17:00 – 17:30

Christine Le Maitre (UK)
Regeneration of the intervertebral disc for back pain targeting the degenerate niche

17:30 – 18:00

Uruj Zehra (PK)
Vertebral endplate changes and back pain: are there any clinically relevant phenotypes?

18:00 – 18:15

JT Marshall, AD Lutton, JW Olesik, BA Walter
Diurnal variations in extracellular and pericellular sodium content of nucleus pulposus tissue

18:15 – 18:30

S Egger, G Alig, M D'Este, JK Wychowaniec, JR Weiser, S Grad, AJ Vernengo
Microextrusion-based anisotropic cell patterning within temperature-sensitive hydrogel matrices for annulus fibrosus regeneration

08:30 – 09:00

Carla Cunha (PT)
Immune cells in IVD therapies: cause, consequence or tool?

09:00 – 09:30

Stefan Dudli (CH)
Disc-bone marrow cross-talk with modic changes

09:30 – 09:45

MP Grant, M Alad, LM Epure, OL Huk, DJ Zukor, J Antoniou, F Mwale
Link N as a modulator of IL-1β-Induced DRG neuronal hypersensitivity in osteoarthritis

09:45 – 10:00

G Vadalà, G Di Giacomo, L Ambrosio, C Cicione, V Tilotta, F Russo, R Papalia, V Denaro Irisin stimulates anabolism and matrix synthesis in human nucleopulpocytes in vitro: new insights into a cross-talk between the muscle and the intervertebral disc

10:00 – 10:15

D Terrazas, T Hopkins, C Thompson, K Wright, H Screen, M Knight
Fibroblast-like synoviocytes modulate the inflammatory response of chondrocytes in a mechanosensitive manner

10:45 – 11:15

Ken Howard (DK)
Biological barriers and delivery solutions for nucleic acid therapeutics

11:15 – 11:30

SN Tang, AI Salazar-Puerta, M Heimann, G Gunsch, C Gantt, T Ko, L Bodine, K Kuchynsky, DM Laudier, S Khan, J Hoyland, B Walter, O Kokiko-Cochran, N Higuita-Castro, D Purmessur
FOXF1 delivery via engineered extracellular vesicles in an in vivo mouse model of discogenic back pain

11:30 – 11:45

KH Li, Y Zhu, PH Zhang, M Alini, S Grad, Z Li
Anti-inflammatory and pro-anabolic effects of 5-aminosalicylic acid on inflammatory human osteoarthritic chondrocytes in vitro

11:45 – 12:00

S Zarzo-Arias, V Leiro, AP Pêgo
Exploring fully biodegradable dendrimers as nanocarriers for siRNA delivery to chondrocytes

12:00 – 12:15

KA Münzebrock, A Pontes, FYW Ho, JP Garcia, J Rip, LB Creemers
Polymeric nanoparticles enable mRNA delivery into cells of human cartilaginous tissues

12:15 – 12:45

Sibylle Grad (CH)     
RMS Foundation Student Awards and conference closing