eCM (Eur Cell Mater / e Cells & Materials)
eCM Periodical and Conferences, Science with Open Discussion
 ISSN 2522-235X

2022 eCM20: Cartilage and Disc Repair and Regeneration
15th – 18th June 2022, Congress Center, Davos, Switzerland

Wednesday, June 15th

Welcome

13:00 – 13:15

Martin Stoddart (CH)

Sibylle Grad (CH)
Conference house keeping
Cartilage and Disc


Session 1: Opening Session and Berton Rahn Award
Chair: Geoff Richards

13:15 – 13:45

Stephen Ferguson (CH) Berton Rahn Research Award winner 2022
ANNUMECH: Experiences and insights from the AO collaborative research program for annulus fibrosus repair

13:45 – 14:15

Jos Malda (NL) Berton Rahn Research Award winner 2021
Converged biofabrication technologies for osteochondral implants

14:15 – 14:45

Ling Qin (HK) Berton Rahn Research Award winner 2020
3D printing and tissue engineering for skeletal regeneration–
achievements from RAPIDOS consortia project

 

14:45 – 15:15 Coffee Break

Session 2: Clinical developments
Chair: Stefan Dudli

15:15 – 15:45

Ivan Martin (CH)
Engineered nasal cartilage for osteoarthritis?

15:45 – 16:15

Keren Bismuth (FR)
Beneficial structural impact of liraglutide, a GLP1 receptor agonist, in inflammatory and post-traumatic OA animal models

16:15 – 16:30

R Hilliard, H Newman, A Barba, L Brewer, E Brewer, Z Brown, P Wilson,
A Lowman, DM Elliott, T Schaer
Nucleus pulposus replacement mitigates IVDD in a caprine model – a 3 year follow-up

 

Session 3: Cells and Organelles
Chair: Catherine Le Visage

16:30 – 17:00

Lisbet Haglund (CA)
Cell senescence and senolytic drugs to treat back-pain in mice and men

17:00 – 17:30

Francisco Blanco (ES)
Mitochondrial DNA variants influence the risk of Knee Osteoarthritis

17:30 – 17:45

P Humbert, M Garcia, L Jabbour, S Grastilleur, E Carrot, S Sourice, B Halgand, D Rouleau, F Etienne, A Lafragette, N Luciani, J Clouet, AKA Silva, F Gazeau, M Fusellier, J Guicheux, C Le Visage
Use of intervertebral disc cells from sheep to evaluate biotherapies in vitro

17:45 – 18:00

GQ Teixeira, J Kräutler, J Riegger, A Ignatius, C Neidlinger-Wilke
Effect of entire MSC secretome versus extracellular vesicles in pro-inflammatory annulus fibrosus cell cultures

18:00 – 18:15

R Ossendorff, V Börger, DC Wirtz, S Grad, B Giebel, FA Schildberg
Extracellular vesicles (MSC-EV) - influence on cartilage regeneration in osteoarthritic surroundings

18:15 – 18:30

 Riegger, L Ruths, G Teixeira, M Huber-Lang, A Ignatius, RE Brenner
Terminal complement complex is a potential inducer of premature senescence in trauma- and age-associated osteoarthritis


18:30 – 20:00 Poster session (Drinks & Snacks)

 

Thursday, June 16th

Session 4: Tissue function and dysfunction
Chair: Benjamin Gantenbein

08:30 – 09:00

Frank Beier (CA)
What do mouse studies teach us about osteoarthritis?

09:00 – 09:30

Ali Mobasheri (CA)
Immunometabolism in disc and cartilage in health and disease

09:30 – 09:45

H Cherif, L Li, J Snuggs, C Sammon, L Beckman, L Haglund, C Le Maitre
Human organ culture model demonstrates potential regeneration of naturally degenerate discs with an injectable hydrogel system

09:45 – 10:00

A Alminnawi, KB Crump, P Bermudez-Lekerika, AS Croft, C Geeroms, C Le Maître, B Gantenbein, L Geris
Image-based analysis of mass transport through cartilage endplates

10:00 – 10:15

R Castro-Viñuelas, N Viudes-Sarrión, S Monteagudo, R Lories, I Jonkers
Excessive wnt signalling alters cartilage’s mechano-response in a human explant in vitro model

10:15 – 10:30

H Meng, S Fu, MB Ferreira, N Gavara, MM Knight
Activation of YAP suppresses cartilage inflammatory signalling and matrix degradation

10:30 – 11:00 Coffee Break


Session 5: Cells in orthopaedics
Chair: Marianna Tryfonidou

11:00 – 11:30

Anne Camus (FR)
Generation of intervertebral disc progenitor cells from human induced pluripotent stem cells

11:30 – 12:00

Solvig Diederichs (DE)
Induced pluripotent stem cells for cartilage regeneration

12:00 – 12:15

LT Laagland, FC Bach, LB Creemers, C Le Maitre, DW Poramba-Liyanage, MA Tryfonidou
Hyperosmolar expansion medium improves canine nucleus pulposus cell phenotype

12:15 – 12:30

S Basatvat, TS Braun, E Kanelis, LG Alexopoulos, J Snuggs, R Williams, M Templin, M Tryfonidou, C Le Maitre
Could notochordal cells be the future of cell-based treatment for disc degeneration?

12:30 – 12:45

G Pattappa, J Jahns, R Schewior, J Zellner, D Docheva, P Angele
Identifying a unique gene profile for the meniscus cells in tissue and in vitro monolayer and pellet cultures

12:45 – 13:00

N Herger, L Arpesella, M Farshad, F Brunner, O Distler, S Dudli
Pro-inflammatory priming of mesenchymal stem cells increases their immunosuppressive properties only short-term

 

Group Photo, Free afternoon & eCM walk

Lunch (Lunch not provided)

18:00 Dinner at Walserhuus Sertig

 


Friday, June 17th

Session 6: Mechanobiology and Modeling
Chair: Hans-Joachim Wilke

08:30 – 09:00

Fabio Galbusera (IT)
Computational modeling and artificial intelligence in spine research

09:00 – 09:30

Ilse Jonkers (BE)
An integrated, multi-scale approach to understand the role of mechanical loading in cartilage homeostasis and disease: Bridging from joint to chondrocyte

09:30 – 09:45

S Midha, T Johnson, CR Coveney, E Stride, JPK Armstrong, AKT Wann
The mechano-regulation of phenotypic plasticity studied in a developmental engineering model of endochondral ossification

09:45 – 10:00

JU Jansen, GQ Teixeira, A Vernengo, S Grad, K Benz, C Neidlinger-Wilke, HJ Wilke
How to create artificial disc degeneration by enzyme digestion for biomechanical testing of biomaterials

10:00 – 10:15

E Salzer, VHM Mouser, J Bulsink, MA Tryfonidou, K Ito
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus explants

10:15 – 10:30

A Ristaniemi, A Šećerović, S Grad, SJ Ferguson
A novel viscoelastic bovine intervertebral disc finite element model

10:30 – 11:00 Coffee Break


Session 7: Tissue engineering and Regenerative medicine
Chair: Matteo D'Este

11:00 – 11:30

Sylvia Nürnberger (AT)
Extracellular matrix as biomaterial for cartilage regeneration – more than a scaffold

11:30 – 12:00

Ling Qin (US)
Developing novel treatments for joint diseases

12:00 – 12:15

P Nakielski, C Rinoldi, M Pruchniewski, D Rybak, O Urbanek, K Jezierska-Woźniak, M Grodzik, W Maksymowicz, F Pierini
Injectable microscaffolds for IVD regeneration

12:15 – 12:30

B Günay, G Targa Fabra, L Laanglard, T Schmitz, K Ito, MA Tryfonidou, R Saldova, A Pandit
Glycomic enhancement of hyaluronic acid-based hydrogel with notochordal cell-derived matrix for disc regeneration

12:30 – 12:45

J Warren, R Cowie, L Jennings, R Wilcox, H Fermor
Self-assembling peptide gels for articular patella cartilage repair

12:45 – 13:00

E Carrot, P de Villemagne, S Grastilleur, B Rosa, B Halgand, V Delplace, J Clouet, P Weiss, Vidal, JY Hascoët, M Fusellier, J Guicheux, C Le Visage
Bioprinting and characterization of a sheep intervertebral disc model

Lunch (Lunch not provided)

Session 8: ORS Spine Session
Chair: Devina Purmessur

17:00 – 17:30

Christine Le Maitre (UK)
Regeneration of the intervertebral disc for back pain targeting the degenerate niche

17:30 – 18:00

Uruj Zehra (PK)
Vertebral endplate changes and back pain: are there any clinically relevant phenotypes?

18:00 – 18:15

JT Marshall, AD Lutton, JW Olesik, BA Walter
Diurnal variations in extracellular and pericellular sodium content of nucleus pulposus tissue

18:15 – 18:30

S Egger, G Alig, M D'Este, JK Wychowaniec, JR Weiser, S Grad, AJ Vernengo
Microextrusion-based anisotropic cell patterning within temperature-sensitive hydrogel matrices for annulus fibrosus regeneration

18:30 – 20:00 Poster session (Drinks & Snacks)


Saturday, June 18th

Session 9: Tissue Crosstalk
Chair: Lisbet Haglund

08:30 – 09:00

Carla Cunha (PT)
Immune cells in IVD therapies: cause, consequence or tool?

09:00 – 09:30

Stefan Dudli (CH)
Disc-bone marrow cross-talk with modic changes

09:30 – 09:45

MP Grant, M Alad, LM Epure, OL Huk, DJ Zukor, J Antoniou, F Mwale
Link N as a modulator of IL-1β-Induced DRG neuronal hypersensitivity in osteoarthritis

09:45 – 10:00

G Vadalà, G Di Giacomo, L Ambrosio, C Cicione, V Tilotta, F Russo, R Papalia, V Denaro Irisin stimulates anabolism and matrix synthesis in human nucleopulpocytes in vitro: new insights into a cross-talk between the muscle and the intervertebral disc

10:00 – 10:15

D Terrazas, T Hopkins, C Thompson, K Wright, H Screen, M Knight
Fibroblast-like synoviocytes modulate the inflammatory response of chondrocytes in a mechanosensitive manner

10:15 – 10:45 Coffee Break

Session 10: Drug and Gene delivery
Chair: Laura Creemers

10:45 – 11:15

Ken Howard (DK)
Biological barriers and delivery solutions for nucleic acid therapeutics

11:15 – 11:30

SN Tang, AI Salazar-Puerta, M Heimann, G Gunsch, C Gantt, T Ko, L Bodine, K Kuchynsky, DM Laudier, S Khan, J Hoyland, B Walter, O Kokiko-Cochran, N Higuita-Castro, D Purmessur
FOXF1 delivery via engineered extracellular vesicles in an in vivo mouse model of discogenic back pain

11:30 – 11:45

KH Li, Y Zhu, PH Zhang, M Alini, S Grad, Z Li
Anti-inflammatory and pro-anabolic effects of 5-aminosalicylic acid on inflammatory human osteoarthritic chondrocytes in vitro

11:45 – 12:00

S Zarzo-Arias, V Leiro, AP Pêgo
Exploring fully biodegradable dendrimers as nanocarriers for siRNA delivery to chondrocytes

12:00 – 12:15

KA Münzebrock, A Pontes, FYW Ho, JP Garcia, J Rip, LB Creemers
Polymeric nanoparticles enable mRNA delivery into cells of human cartilaginous tissues

12:15 – 12:45

Sibylle Grad (CH)     
RMS Foundation Student Awards and conference closing

Conference End


We advise all presenters to look at the TIPS FOR TALKS (548 kB) presentation and read these guidelines (39kB) before starting to prepare their talks. Science is in the detail. It is the lifeblood of science to discuss.

All invited talks are 20 minutes (20-30 slides) to allow 10 minutes discussion per talk.
All submitted talks are 10 minutes (10-15 slides) to allow 5 minutes discussion per talk.

Chairpersons will cut people off who try to use this time for their talks!
Please bring a copy of your talk on CD or USB stick to give to Presentation Support, Sunday morning at Registration.

Paper Submission
We invite all keynote speakers to submit a paper (either original research report, original review*or original tutorial*) to the European Cells & Materials (eCM) online 'Open & Free Access' journal.*NOTE: We define a REVIEW PAPER as a paper which includes an extended literature review and complete bibliography (including authors' own work), and can also emphasise authors' new unpublished findings and in an extended discussion puts the topic in proper perspective. A review can also be based on a complete bibliography of an author's own work over several years in relation to others. A TUTORIAL PAPER contains an organised comprehensive review of all relevant published material as for a teaching lecture.

 


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