eCM (Eur Cell Mater / e Cells & Materials)
eCM Periodical and Conferences, Science with Open Discussion
 ISSN 2522-235X

2019 eCM XIX: Orthopaedic Infection 26th – 28th June 2019, Congress Center, Davos, Switzerland

Full Conference Program (4.2MB)

Wednesday, June 26th

Conference Opening

08:45 – 09:15

Geoff Richards (CH)
20 years of eCM Conferences & Journal

Fintan Moriarty (CH)
Bone infection, the issues
Conference house keeping

Opening Session 1: Clinical problem of orthopaedic infection
Chair: Geoff Richards/Jaime Quintero

09:15 - 09:45

Hamish Simpson (UK)
Musculoskeletal infection in trauma: surgical and antibiotic treatment

09:45 - 10:15

Willem-Jan Metsemakers (BE)
Berton Rahn winner: Fracture related infection

10:15 - 10:45

Josh Wenke (US)
Challenges and strategies of protecting orthopaedic implants from bacterial colonization


10:45 – 11:15 Coffee Break

Session 2 Risk factors in orthopaedic infection
Chair: Gerald J Atkins/Hamish Simpson

11:15 – 11:45

Robert Mooney (US)
Host and S. aureus factors influence orthopaedic infection severity in obesity and type 2 diabetes

11:45 – 12:15

Christopher J Hernandez (US)
The microbiome and orthopaedic implant infection

12:15 – 12:30

D Gil, S Grindy, S Hugard, O Muratoglu, E OralPrevention of periprosthetic joint infections using analgesic-loaded UHMWPE

12:30 – 12:45

K Thompson, MA Burch, A Milstrey, U Eberli, D Arens, RG Richards,
VA Stadelmann, TF MoriartyNon-steroidal anti-inflammatory drug administration impairs antibiotic treatment of orthopaedic-device related infection in a rat model

12:45 – 13:00

S Karbysheva, S Cabric, A TrampuzBiofilm investigation on ceramic, metal and polyethylene bearing components from explanted hip joint replacement systems


Free afternoon

Session 3 AOTrauma Clinical priority program bone infection
Chair: Robert A Mooney/Josh Wenke

17:00 – 17:15

Geoff Richards (CH), Edward M Schwarz (US)
Information about ORS Research interest group

17:15 – 17:45

Stephen L Kates (US)
The AOTrauma bone infection registry

17:45 – 18:15

Edward M Schwarz (US)
Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunization for patients with S. aureus osteomyelitis

18:15 – 18:30

EA Masters, AT Salminen, KL de Mesy Bentley, JL McGrath, SR Gill,
HA Awad, EM SchwarzCloning the haptotaxis and durotaxis genes responsible for S. aureus invasion of the osteocytic lacuno-canalicular network during chronic osteomyelitis

18:30 - 18:45

W Boot, T Schmid, O Guillaume, M D'Este, A Foster, D Eglin, RG Richards,
S Zeiter, TF MoriartyAntibiotic-loaded hydrogel demonstrates superior efficacy to bone cement in treating MRSA implant-associated osteomyelitis in sheep

18:45 - 19:00

J Puetzler, A Milstrey, J Everding, M Raschke, D Arens, S Zeiter, RG Richards, TF MoriartyCombination of high-energy focused extracorporeal shockwave therapy
with conventional treatment: Results from an in vivo rabbit model of fracture related infection

19:00 – 20:00 Poster session (Drinks & Snacks)


Thursday, June 27th

Session 4 3D printing in orthopaedic infection (PrintAid)
Chair: Sebastian AJ Zaat / David Eglin

09:00 - 09:30

Harrie Weinans (NL)
Why 3D printing for implant infections?

09:30 – 10:00

Gianluca Ciardelli (IT)
Biomimetic polymers as drug-free antibacterial materials and coatings

10:00 – 10:11

I Reigada, K Savijoki, Y Kauhaluoma, T Jari, A FallareroStrategies to prevent biomaterials from S. aureus infections: effect of dehydroabietic acid derivatives on biomaterials pre-incubated with human cells

10:11 – 10:22

J Allkja, AE Parker, NF Azevedo, DM Goeres
Principles of method standardization

10:22 – 10:33

CM Guarch Pérez, D Martínez-Pérez, W Święszkowski, M Riool, SAJ Zaat
Is gelatin metacrylate the future 3D Printing antimicrobial coating?

10:33 – 10:44

D Martínez Pérez, C Guarch Pérez, I Reigada, A Fallarero, E Choińska, SAJ Zaat, W Święszkowski
3D printed hybrid antimicrobial coating for prevention of implant-associated osteomyelitis

10:44 – 11:15 Coffee Break

Session 5 Bone as niche for staphylococcal infection
Chair: Stephen Kates / Edward Schwarz

11:15 – 11:45

Gerald Atkins (AU)
The involvement of osteocytes in S. aureus deep bone infections

11:45 – 12:15

James E Cassat (US)
Bone appetit: Host-pathogen interactions during osteomyelitis

12:15 – 12:30

KL de Mesy Bentley, MS Chad, A Galloway, MJ Ninomiya, SL Kates, EM Schwarz
Immunogold labeling of S. aureus to survey human infected bone tissue

12:30 – 12:45

EJ Sheehy, C von Diemling, TF Moriarty, FJ O’Brien
Antibiotic-eluting scaffolds eradicate infection and facilitate bone regeneration in a rabbit model of osteomyelitis

12:45 – 13:00

JM Gilbertie, LV Schnabel, TP Schaer
Use of platelet rich plasma lysate improves outcomes of S. aureus infectious arthritis in horses

13:00 – 13:15

IAJ van Hengel, NE Putra, MWAM Tierolf, MB Minneboo, AC Fluit, HH Weinans, SA Yavari, LEF Apachitei, I Apachitei, AA Zadpoor
Additively manufactured bone implants to prevent implant associated infection

13:15 – 13:30

M Cámara-Torres, S Duarte, R Sinha, M Bastianini, M Sisani, M Scatto, A Egizabal, A Patelli, C Mota, L Moroni
3D additive manufactured scaffolds with antimicrobial activity for bone tissue regeneration

Group Photo & Free afternoon

18:00 Conference Dinner at Ischalp

Friday, June 28th

Session 6 Staphylococcus aureus host pathogen interactions
Chair: James E Cassat / Llinos Harris

09:00 – 09:30

Barbara Bröker (DE)
Immune control of S. aureus in the post-genomic era

09:30 – 10:00

Annelies Zinkernagel (CH)
Clinical perspective of chronic –recurring staphylococcal infections

10:00 – 10:15

G Muthukrishnan, JD Brodell, CC Lee; CA Beck, C Ackert-Bicknell, JL Daiss,  EM Schwarz
Anti-staphylococcal antibodies from circulating plasmablasts can diagnose and differentiate various S. aureus orthopaedic infections

10:15 – 10:30

JM Gilbertie, LV Schnabel, NJ Hickok, TP Schaer
Bacterial aggregation in equine synovial fluid shows similarities to traditional biofilms and increased antimicrobial recalcitrance in vitro


10:30 – 11:00 Coffee Break

Session 7 Innovations in biomaterials and in vitro systems
Chair: Barbara Bröker / Andrej Trampuz

11:00 – 11:30

Cornelia Lee-Thedieck (DE)
Mimicking the bone marrow in health and disease: 3D in vitro models to unravel the triangle interaction of host, bacteria and implant material in osteomyelitis

11:30 – 12:00

Bingyun Li (USA)
Immune stimulating biomaterials for orthopedic infection

12:00 – 12:15

D Hürlimann, S Rigo, K Langowska, G Gunkel-Grabole, WP Meier, CG Palivan
Functional surfaces based on immobilized polymeric nanostructures

12:15 – 12:30

SET Louth, K Nai, MM Atallah, SC Cox
Investigating mechanical and elution properties of a novel hip spacer


12:30-14:00 Lunch (Lunch not provided)


Session 8 Bacteriophage therapy for orthopaedic infection
Chair: Annelies Zinkernagel / Willem-Jan Metsemakers

14:00 – 14:30

Andrej Trampuz (DE)
Bacteriophage therapy for biofilm infections: myth or reality?

14:30 – 15:00

Rob Lavigne (BE)
Phage biology and its potential for antibacterial design strategies

15:00 – 15:15

M Di Luca, A Materazzi, AB Klatt, A Tavanti, A Trampuz
Treatment of methicillin-resistant S. aureus biofilm: administration of Sb-1 bacteriophage in a galleria mellonella model of implant-associated infection

15:15 – 15:30

C Röhrig, M Huemer, A Sobieraj, A Keller, N Keller, P Phothaworn, L Zinsli, F Eichenseher, Y Shen, S Korbsrisate, AS Zinkernagel, MJ Loessner, M Schmelcher
Engineered peptidoglycan hydrolases as therapeutics for S. aureus infections

15:30 – 15:45

Awards and conference closing

Conference End

We advise all presenters to look at the TIPS FOR TALKS (548 kB) presentation and read these guidelines (39kB) before starting to prepare their talks. Science is in the detail. It is the lifeblood of science to discuss.

All invited talks are 20 minutes (20-30 slides) to allow 10 minutes discussion per talk.
All submitted talks are 10 minutes (10-15 slides) to allow 5 minutes discussion per talk.

Chairpersons will cut people off who try to use this time for their talks!
Please bring a copy of your talk on CD or USB stick to give to Presentation Support, Sunday morning at Registration.

Paper Submission
We invite all keynote speakers to submit a paper (either original research report, original review*or original tutorial*) to the European Cells & Materials (eCM) online 'Open & Free Access' journal.*NOTE: We define a REVIEW PAPER as a paper which includes an extended literature review and complete bibliography (including authors' own work), and can also emphasise authors' new unpublished findings and in an extended discussion puts the topic in proper perspective. A review can also be based on a complete bibliography of an author's own work over several years in relation to others. A TUTORIAL PAPER contains an organised comprehensive review of all relevant published material as for a teaching lecture.


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